SFCM_09_19: SYNTHESIS OF MAGNETIC NANOPARTICLES WITH BIOMEDICAL APPLICATIONS
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LATEST ADVANCES IN THE SYNTHESIS OF MAGNETIC NANOPARTICLES FOR BIOMEDICAL APPLICATIONS MARÍA DEL PUERTO MORALES MATERIALS SCIENCE INSTITUTE OF MADRID SUPERIOR COUNCIL FOR SCIENTIFIC RESEARCH MONDAY, APRIL 12, 2010 AT 9:30 A.M. ATTENDANCE TO THE SEMINARS CAN BE RECOGNIZED AS THREE CREDITS FREE ADMISSION UNTIL SEALED For more information, contact: PROF. JOSÉ YGNACIO PASTOR, ORGANIZER AND SCIENTIFIC COORDINATOR Department of Materials Science. Polytechnic University of Madrid ETSI Caminos, Canales y Puertos, Floor --1. The use of magnetic nanoparticles in biomedicine is an approach with great potential in the diagnosis and treatment of different diseases [1]. In particular, small iron oxide particles are already used as contrast agents in nuclear magnetic resonance images for the observation of blood vessels, macrophages and cell tracking [2]. A very interesting application under study is the use of these nanoparticles for the detection and treatment of brain lesions in the case of neurodegenerative diseases. In this talk we will show the synthesis of uniform magnetite nanoparticles of different sizes by thermal decomposition in an organic medium that allows obtaining particles with controlled size and shape [3]. These particles have shown excellent magnetic properties despite their small size due to high crystallinity and the presence of oleic acid on the surface. The oleic acid-coated particles have been transferred to water by exchanging the oleic acid for dimercaptosuccinic acid (DMSA), which gives the particles high stability in water at pH 7 and free carboxyl groups to conjugate biomolecules. A relationship has been established between particle size, aggregate size, magnetic properties and relaxivity values [4]. Finally, it will be shown how the chemical and biochemical properties of the particles affect their interaction with cells, tissues and organs, as well as the accumulation and elimination of nanoparticles in various organs. SEMINARS ON FRONTIERS OF MATERIALS SCIENCE DEPARTMENT OF MATERIALS SCIENCE POLYTECHNIC UNIVERSITY OF MADRID LATEST ADVANCES IN THE SYNTHESIS OF MAGNETIC NANOPARTICLES WITH BIOMEDICAL APPLICATIONS MARÍA DEL PUERTO MORALES INSTITUTE OF MATERIALS SCIENCE OF MADRID SUPERIOR COUNCIL OF SCIENTIFIC RESEARCH MONDAY, APRIL 12, 2010 Video Produced by the Tele-Education Office of the Polytechnic University of Madrid.
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