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Lecture given at the School of Philosophy of Oviedo on October 9, 2023. https://www.fgbueno.es/efo/efo314.htm Tomás García López prepared, for the 28th Philosophy Meetings. Philosophy, artificial intelligence and new technologies (held in Salamanca from Friday, September 29 to Sunday, October 1, 2023) a presentation that, due to its very nature and breadth, seemed appropriate to be offered in two parts: the first at the Meetings and its continuation in this EFO lesson. Man-machine and man's machines I. Historical and philosophical coordinates to frame Julien-Offray de la Mettrie's work Man-machine. II. Some notes on the scientific and philosophical influences that worked in the elaboration of this work, based on its own citations. III. Gnoseology of the Man-Machine: 1) The Man-Machine as a medical and military anthropology. 2) The lights of his anatomy and physiology, as α methodologies of the study of man, reflected even in his β-operative physiognomy notes. 3) The shadows of his embryology, projected on The Man-Machine: Theory of the animalcule. 4) Anticipated formulation of the principle of the Ignoramus, Ignorabimus, and paradoxical application to some of his studies. IV. Ontology of the Man-Machine: What kind of materialism is the materialism of Julien-Offray de la Mettrie? V. Ethics of the Man-Machine of La Mettrie: 1) Human passions and vices. 2) Virtues and human Happiness: From what model of Happiness does La Mettrie use the concept of Happiness and outline a theory and a doctrine of happiness? VI. From La Mettrie's Man-Machine to man-machines in times of Artificial Intelligence.