Mechanisms of Long COVID and the Path to Therapeutics - DOI: 10.1016/j.cell.2024.07.054 There is also a timestamp at the beginning of the video. 0:00 Introduction 09:30 Central theme of the publication 16:58 Peer review of side effects of the corona vaccination 20:43 Clinical features of long Covid 23:55 Conceptual framework Mechanisms of long Covid 25:38 Biological causes 29:22 Nattokinase 44:27 Consequences of an acute infection 55:25 Post-acute virus persistence 1:04:14 Post-acute inflammation 1:19:49 B-cell reactions and autoimmunity 1:27:39 Thrombotic events and microclots 1:34:28 Reactivation of latent virus infections 1:38:42 Changes in the microbiome and microbial translocation 1:41:49 Mitochondrial dysfunction and metabolic disorders 1:45:04 Clinical physiology of long Covid 2:06:51 The path to clinical trials 2:11:15 Conclusions Proposed framework for defining PASC Long COVID epidemiology Risk factors and protective factors for long COVID Clinical features of long COVID A conceptual framework for the mechanisms of COVID Conceptual model for the mechanisms driving long COVID Upstream and onstream: Biological drivers of long COVID Biological mechanisms of long COVID Potential links between the biological mechanisms of long COVID Mechanismal targets of long COVID prevention and treatment Physiological models of long COVID The consequences of acute infection Viral persistence beyond the acute infection Inflammatory persistence after the acute infection B cell responses and autoimmunity Thrombotic events and microclots Reactivation of previous viral infections Microbiome changes and microbial translocation Mitochondrial dysfunction and metabolic disorders Clinical physiology of long COVID End-organ tissue damage Endotheliitis, endotheliopathy, thrombus inflammation, tissue oxygen deficiency (tissue hypoxia) Neuropathy and dysautonomia Disruption of the gut-brain axis Primary neurocognitive dysfunction The importance of gender The need for replacement biomarkers Experimental medicine to investigate the mechanisms Addressing regulatory problems (bureaucracy) etc. More information at: www.dr-wiechert.com Also take a look at the newsletter archive, use the search function. You can find this study in the newsletter from October 13, 2024 If you subscribe to the newsletter, you will regularly receive valuable information about health. More information on the topic in the newsletters: https://www.google.de/search?q=PRM&as... Please note: The information and recommendations presented here are for general information purposes only and are neither advertising nor advisory in nature. In no case do they replace the individual, personal advice of a doctor and are not medical help. Treatment without consultation with a doctor in this field - especially in the case of known