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The acute attack of gout that affects the metatarsophalangeal joint of the big toe gives rise to one of the most intense pains that can strike us. But this inflammatory pathology also has strong systemic implications and can also affect other organs and systems. We talk about it with Prof. Roberta Ramonda, Professor of Rheumatology, University of Padua, whom we met at the rheumatology congress in Rimini.