Video description. A detailed explanation of the causes of aspirin asthma. Aspirin asthma is a disease in which symptoms, mainly asthma attacks, appear when certain antipyretics and analgesics are taken orally. Although the name of the disease includes the name of the drug "aspirin," the symptoms are actually caused by non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs are commonly used in antipyretics and analgesics for adults and over-the-counter cold medicines. For this reason, aspirin asthma is sometimes called "NSAIDs hypersensitivity asthma" or "antipyretic analgesic asthma." It is rare in childhood, and is thought to account for approximately 10% of adult asthma cases. Phospholipids in cell membranes are metabolized to arachidonic acid (AA) by phospholipase A2. AA is converted to prostaglandins (PG) by cyclooxygenase (COX), and leukotrienes (LT) by lipoxygenase (LO). Why do NSAIDs promote the production of leukotrienes and cause bronchoconstriction? This is because the selective inhibition of COX activates the other pathway (LO), promoting the production of LT. Patients with aspirin-induced asthma already have an enhanced LT system, which further increases its activity and causes bronchoconstriction. Effect of acetaminophen on COX It is said that the inhibition of the synthesis of prostaglandins involved in the body temperature center is the same as that of aspirin, but the inhibition of prostaglandin synthesis in the periphery is said to be extremely weak compared to aspirin. It has almost no effect on body temperature at normal temperatures, and its maximum effect is expressed about 3 hours after administration during fever. Its analgesic effect is limited to mild pain, just like aspirin. It has almost no anti-inflammatory effect. Effect of sulpyrine on COX Sulpyrine hydrate exhibits an antipyretic effect by inhibiting cyclooxygenase (COX), the rate-limiting enzyme in prostaglandin biosynthesis, and suppressing the production of prostaglandins. Like NSAIDs, it may cause aspirin-induced asthma. Atopic asthma (allergic asthma) Delayed asthmatic reactions may occur to inhaled allergens. After exposure, airway hypersensitivity increases for several hours to several days, but the detailed mechanism is unknown. Unlike hypersensitivity pneumonitis, this is a type I allergy. Wheezing and asthma due to type I allergy caused by anaphylaxis of drugs, as well as aspirin and other N-seize and pyrazinergic drugs, have also been confirmed. There are also many drugs that cause asthma through other mechanisms. Generic name: Sildenafil Generic name: Sildenafil citrate English generic name: Sildenafil Citrate Formulation name: Sildenafil citrate tablets Medicinal classification: Erectile dysfunction treatment Other side effects: Respiratory rhinitis, respiratory disorders, nasal congestion, pharyngitis, asthma, nosebleeds, respiratory tract infections, sinusitis #Aspirin asthma #Drug-induced asthma Please subscribe to the channel. Click here to subscribe to the channel. / @shinzouchannel