Basic pharmacology of antianginal drugs
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The lecture presents the basics of the pharmacology of drugs used in ischemic heart disease. The lecture was prepared using materials from the Department of Pharmacology of the Institute of Cardiology and Mathematics (Associate Professor Petrova V.E. and Assoc. Professor Gorbunova A.A.) ** ATTENTION! All information presented in this video is for educational and informational purposes only. The author is not responsible for any possible consequences of self-medication with the drugs (medications) mentioned in the video. Remember that only the attending physician can prescribe drugs or change the treatment regimen during an in-person consultation. *** TIME CODES 0:00 Introduction 0:27 Coronary blood flow in normal conditions and with ischemic heart disease 1:44 Ischemic heart disease: acute and chronic 2:57 Types of stable angina 4:54 O2 demand and O2 delivery to the myocardium 9:29 What do demand and delivery depend on? 11:44 Classification of antianginal drugs 14:05 Classification of beta-blockers 16:03 Cardiac effect of beta-blockers 20:43 Mechanism of antianginal action of beta-blockers 21:02 Beta-blockers with additional vasodilatory properties 24:07 Physicochemical properties of beta-blockers 29:39 Beta-blockers: use in coronary artery disease 30:35 Beta-blockers: effect on coronary blood flow 32:06 Typical side effects of beta-blockers 34:20 Ivabradine 36:57 Ranolazine 39:49 Organic nitrates: main representatives 40:30 Mechanism of vasodilatory effect of organic nitrates 44:36 Mechanism of antianginal effect of organic nitrates 45:39 Effect of organic nitrates on coronary blood flow 47:29 Organic nitrates: use in ischemic heart disease 49:30 Side effects of organic nitrates 51:02 Tolerance to the effects of organic nitrates 56:11 Molsidomine 56:52 Calcium channel blockers (CCB): classification 59:02 Mechanism of vasodilatory and cardiotropic action of CCB 1:04:00 Mechanism of antianginal action of CCB 1:05:18 Features of the pharmacokinetics of CCB 1:07:24 CCB: use in ischemic heart disease 1:08:38 Side effects of CCB 1:12:48 Nicorandil 1:14:12 Dipyridamole
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