What Are AlphaFold and Rosetta (And Why They Won the Nobel Prize in Chemistry)
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AlphaFold and Rosetta are artificial intelligence software that very few have revolutionized the world of biology, in particular the field of protein folding, the folding of proteins. The Nobel Prize in Chemistry 2024 was awarded to three biologists: David Baker, Demis Hassabis and John M. Jumper won the Nobel Prize in Chemistry for their studies on the structures of proteins. Their merit was precisely the development of these two software, which thanks to the use of deep learning, solved a 50-year-old mystery. But what are AlphaFold and Rosetta? And why is this discovery considered revolutionary? In this video, we explore how these two AIs were able to predict and design protein structures with unprecedented precision, forever changing the way we approach scientific research and drug development. We will discover: Why predicting the structure of proteins was so difficult. How AlphaFold and Rosetta turned a dream into reality. The enormous impact that this discovery has on biology, medicine and biotechnology. ???? Did you know? Thanks to AlphaFold, we now know the structure of almost every protein known to science. And Rosetta is already designing proteins for new drugs, vaccines, and even to fight climate change. If you want to find out how these AIs work, why they are so important, and how they are already changing our lives, this video is for you! 〰〰〰〰〰〰〰〰〰〰〰〰〰 Hello, person! ☕ If you like these videos and want to support DNA a colazione you can join the Laboratory (Tipeee) https://it.tipeee.com/colazione/ ????INSTAGRAM: / dna_a_colazione 〰〰〰〰〰〰〰〰〰〰〰〰〰〰 SOURCES: Design of a Novel Globular Protein Fold withAtomic-Level Accuracy (Brian Kuhlman et al., 2023) https://pubmed.ncbi.nlm.nih.gov/14631... AI protein-prediction tool AlphaFold3 is now more open (Ewen Callaway, 2024) https://www.nature.com/articles/d4158... How AI protein structure prediction and design won the Nobel prize (Jamie Durrani, 2024) https://www.chemistryworld.com/featur... De novo designed proteins neutralize lethal snake venom toxins. (David Baker et al, preprint) https://pubmed.ncbi.nlm.nih.gov/38798... Principles of Biochemistry (Donald Voet, Judith G. Voet, Charlotte W. Pratt, 2017)
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