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Globally, depression, manifesting itself through physical, emotional and cognitive symptoms, is the leading cause of disability. In our country, the prevalence is 5%, equal to approximately 3 million people, of which 1 million suffer from major depressive disorder (MDD) and only about half receive adequate diagnosis and treatment. Today, new therapies are available, explained to us by Prof. Antonio Vita, full professor of psychiatry at the University of Brescia. Director of the Department of Mental Health of Brescia and Vice President of the Italian Society of Psychiatry (SIP)