Original video by Mark Kaufman • CARE SYSTEMS: SKIN CYCLE... Telegram channel about skin treatment from docmed dermatologist Zhangir Zeynolla A MAN ABOUT SKIN (he has a lot there about systemic retinoids) https://t.me/acnesskincare Scientific work on the results of 40 years of topical use of tretinoin (open access with links to all articles): https://cutt.ly/EwSJ4yeu 50 years (a more modern version, not openly available, paid) https://cutt.ly/awSJ4oCa Topical tretinoin and wound healing: Paquette D, Badiavas E, Falanga V. Short-contact topical tretinoin therapy to stimulate granulation tissue in chronic wounds. J Am Acad Dermatol. 2001;45(3):382-386. Popp C, Kligman AM, Stoudemayer TJ. Pretreatment of photoaged forearm skin with topical tretinoin accelerates healing of full-thickness wounds. Br J Dermatol. 1995;132(1):46-53. Anthony J, Miller L, Dinehart SM. Topical tretinoin decreases healing times of electroepilation-induced wounds. Dermatologica. 1991;183(2):129-131. Basak PY, Eroglu E, Altuntas I, Agalar F, Basak K, Sutcu R. Comparison of the effects of tretinoin, adapalene and collagenase in an experimental model of wound healing. Eur J Dermatol. 2002;12(2):145-148. Topical tretinoin and its effect on the fetus during pregnancy: Jick SS, Terris BZ, Jick H. First trimester topical tretinoin and congenital disorders. Lancet. 1993;341(8854):1181–1182. On the low absorption of topical tretinoin: Latriano L, Tzimas G, Wong F, Wills RJ. The percutaneous absorption of topically applied tretinoin and its effect on endogenous concentrations of tretinoin and its metabolites after single doses or long-term use. J Am Acad Dermatol. 1997;36(3 Pt 2):S37–S46. Renova (tretinoin cream) 0.02%, package insert. Los Angeles, CA: Ortho Dermatologics, a Division of Ortho-McNeil-Janssen Pharmaceuticals, Inc; 2008. That study about tretinoin and lung cancer: Katz KA. Topical tretinoin, lung cancer, and lung-related mortality. Arch Dermatol. 2008;144(7):945-946. Topical tretinoin and the treatment of photodamage: Mukherjee S, Date A, Patravale V, Korting HC, Roeder A, Weindl G. Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clin Interv Aging. 2006;1(4):327-348. Babamiri K, Nassab R. Cosmeceuticals: the evidence behind the retinoids. Aesthet Surg. 2010;30(1):74-77. Serri R, Iorizzo M. Cosmeceuticals: focus on topical retinoids in photoaging.Clin Dermatol. 2008;26(6):633-635. Topical tretinoin in the treatment of melasma: Rendon M, Berneburg M, Arellano I, Picardo M. Treatment of melasma. J Am Acad Dermatol. 2006;54(Suppl 5):S272-S281. Topical tretinoin and skin cancer prevention (putative effect): Prystowsky JH. Topical retinoids. In: Wolverton SE, ed. Comprehensive Dermatologic Drug Therapy. Philadelphia, PA: WB Saunders Company; 2001;578-594. Zhang H, Rosdahl I. Expression profiles of p53, p21, bax and bcl-2 proteins in all-trans-retinoic acid treated primary and metastatic melanoma cells. Int J Oncol. 2004;25(2):303-308. Topical tretinoin in the treatment of stretch marks and scars: Ash K, Lord J, Zukowski M, McDaniel DH. Comparison of topical therapy for striae alba (20% glycolic acid/0.05% tretinoin versus 20% glycolic acid/10% L-ascorbic acid). Dermatol Surg. 1998;24(8):849-856. Rangel O, Arias I, GarcÃa E, Lopez-Padilla S. Topical tretinoin 0.1% for pregnancy-related abdominal striae: an open-label, multicenter, prospective study. Adv Ther. 2001;18(4):181-186. Topical tretinoin in the treatment of rosacea: Ertl GA, Levine N, Kligman AM. A comparison of the efficacy of topical tretinoin and low-dose oral isotretinoin in rosacea. Arch Dermatol.1994;130(3):319-324. Yamasaki K, Kanada K, Macleod DT, et al. TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes. J Invest Dermatol.2011;131(3):688-697. Topical tretinoin in the treatment of psoriasis: Kaidbey KH, Petrozzi JW, Kligman AM. Treatment of psoriasis with topically applied tretinoin and steroid ointment. Arch Dermatol. 1975;111(8):1001-1003. McMichael AJ, Griffiths CE, Talwar HS, et al. Concurrent application of tretinoin (retinoic acid) partially protects against corticosteroid-induced epidermal atrophy. Br J Dermatol. 1996;135(1):60-64. __ ???? My Telegram channel Beauty vanity: https://t.me/klavagolman ???? Podcast Bez suety https://bezsuety.mave.digital My store with accessories: https://klavagolman.com/shop E-mail for cooperation: [email protected] Time codes 00:00 Introduction 02:39 everything you need to know about RETINOIDS 03:45 systemic retinoids (which we drink, not smear) 04:29 contraindications for taking ISOTRETIN 05:25 side effects of ISOTRETIN 08:11 external RETINOIDS (which we smear, not drink) 10:45 side effects of external RETINOIDS (all) 12:34 external TRETINOIN and lung cancer 13:36 REACTION to MARK KAUFMAN's video