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What are the points that cross the clinical path of drug addiction at the beginning of a treatment? The beginning of treatment in psychoanalysis is marked by the function of preliminary interviews, in which the rules of treatment and transference are established and the elements for the realization of the structural diagnosis are sought. Therefore, the distinction between phenomenon and structure is fundamental because it directs the clinical management in the treatment of users of psychoactive substances. According to psychoanalysis, preliminary interviews provide the starting point for identifying the levels of operability of the signifier Name-of-the-Father for each subject and the singularity of the symptom at the beginning of the treatment.