Lecture for Pascoe on December 4th, 2024 in Hamburg. The lecture examines in detail the connections and mechanisms behind long COVID and post-vaccine syndrome, two complex and increasingly common health challenges. Both conditions are described as chronic inflammatory processes that can have profound effects on the entire body. Persistent spike proteins, which can enter the body through both the virus and mRNA vaccines, play a central role. These proteins cause damage to the inner wall of the blood vessels (endothelialitis), microcirculation disorders and immunological dysregulation. This leads not only to autoimmune reactions, but also to a variety of symptoms such as brain fog, chronic fatigue, cognitive impairment and neurological symptoms that are due to neuroinflammation and disrupted blood-brain barriers (leaky brain). Typical complaints also include muscle weakness, circulatory disorders, sleep disorders and vascular problems such as microthrombosis, which cause a restricted supply of oxygen and nutrients to the tissue. Diagnostics include measuring inflammatory markers such as interleukin-6, TNF-alpha and VEGF, but also specific tests for microthrombosis (e.g. D-dimers) and persistent spike proteins. Mast cell activation syndromes (MCAS) and mitochondrial dysfunctions also play an important role. Stool diagnostics to analyze the microbiome are also considered essential, as the condition of the intestinal system (gut-brain axis) is crucial for immune regulation. The therapeutic approaches include a combination of detoxification, immune modulation and symptom-oriented measures. Apheresis (blood purification) and chelation therapies help to remove environmental toxins, spike proteins and autoantibodies, while mitochondrial therapies and antioxidant measures support cell metabolism. Histamine blockers and the stabilization of mast cells are used to regulate inflammatory processes. An anti-inflammatory diet and the rehabilitation of the microbiome are also among the central therapeutic measures. In the case of cognitive complaints, attempts are made to increase the BDNF (Brain-Derived Neurotrophic Factor) in order to promote nerve regeneration, while circulatory disorders are treated specifically with laser therapy and capillary microscopy. The social dimension of Long-COVID and Post-Vac Syndrome should not be underestimated. The increasing number of those affected poses immense challenges for the healthcare system, especially since differentiating between the two syndromes is often difficult. Dr. Steinmeier emphasizes the need for better education about the long-term effects of infections and vaccinations as well as a differentiated scientific discussion. Long-COVID and Post-Vac Syndrome are complex clinical pictures that require in-depth diagnostics and individually adapted, holistic therapy. The focus is not only on alleviating symptoms, but also on treating the underlying causes sustainably.