PSSD Therapy
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PSSD is a condition in which, when antidepressants with a serotoninergic component are suspended, sexual disorders appear or persist (usually they persist because they were already present while taking the therapy). It is a syndrome that is still little studied and understood, but there is certainly some truth in it if, since 2019, pharmaceutical companies have been forced by the European Medicines Agency to include it among the possible side effects. The real incidence is unknown but reports are increasing; the fact remains that this syndrome, at the moment, seems relatively rare, that is, usually, once the serotoninergic component is suspended, sexuality returns intact. As for therapy, there are currently several options, although none of them has been included in an official therapeutic protocol. The main drugs used, with more or less marked efficacy and with a more or less lasting positive effect, are dopaminergic and noradrenergic, sometimes in combination; among the dopaminergic we mention Cabergoline (which works especially where there is also a marked increase in prolactinemia); Amantadine; Pramipexole; Bupropion (which is still very weak as a dopaminergic). Among the noradrenergics we can mention: Reboxetine, Bupropion (which is a strong noradrenergic) and Nortriptyline. There are then many other molecules that can help such as Imipramine, Yohimbine, Buspirone and others. However, the main concept is this: as excess serotonin inhibits sexuality in all its phases and manifestations, dopamine above all and to some extent noradrenaline are friends of sexuality. One last suggestion: although it is more than understandable that such a disorder becomes a prevalent thought for people who suffer from it, avoid making it a depressing obsession because obsessiveness aggravates all the disorders. Furthermore, for males, avoid abusing pornography and masturbation with the aim of testing yourself because this combination aggravates the problems already present. A. Mercuri
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