Electrophilic Aromatic Substitution – Part 1 //// Organic Reaction Mechanisms

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Published on Nov 29, 2020
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To discuss Electrophilic Aromatic Substitution (SEAr) reactions, we will use two videos. In this part 1, we begin by discussing the general mechanism of this type of transformation, making considerations about its potential energy diagram and the main intermediate of the reaction: the arenium cation. We also discuss the existing spectroscopic evidence, which reinforces the possibility of the existence of the arenium cation. Next, we address the processes behind the formation of the different electrophiles of SEAr reactions: halogenation, nitration, sulfonation, Friedel-Crafts alkylation and Friedel-Crafts acylation. To close the video, we make some comments about the acylation process in the context of preparative organic chemistry. ---- Work licensed under https://creativecommons.org/licenses/... This video was prepared as part of the asynchronous follow-up material for the discipline “Organic Reaction Mechanisms”, of the Bachelor's Degree in Chemistry at the Federal University of ABC, for the emergency supplementary school period from September 21 to December 12, 2020. I hope it can be useful for other people as well, from students to those curious about Organic Chemistry. – FH Bartoloni ----

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