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At the pharmacological level, there have been significant advances in the treatment of chronic inflammatory intestinal diseases; it has been observed that therapy with biological drugs loses its effectiveness over time. Small molecules act inside the cell and are not immunogenic; they are therefore effective in the long term and are absorbed orally, without interference with food. Numerous clinical studies are underway to evaluate efficacy and quality of life. These topics are on the agenda in Milan of the “Clinical Challenges” course in gastroenterology and digestive endoscopy. Dr. Stefania Carmagnola and Dr. Alessandro Massari, gastroenterologists, ASST Fatebenefratelli- Sacco Milano, talk about it on PharmaStar.