Antidepressant-induced sexual dysfunction: Amantadine

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Dott. Angelo Mercuri

Published on Sep 3, 2024
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One of the most annoying and debilitating side effects of the use of serotonergic antidepressants is the impairment of sexual activity in both men and women, a very common effect that affects, albeit with variable intensity, the majority of patients and most of the time it arises in the first few days of treatment and persists for the entire duration of the treatment (although there are fortunate cases in which it attenuates and disappears over time). It therefore seems that it is mainly the excess of serotonin induced by antidepressants that causes a drop in dopaminergic activity in certain regions of the nervous system, which is then responsible for all the sexual disorders caused by these drugs. Dopaminergic drugs can therefore restore the lost balance between serotonin and dopamine altered by the excess of serotonin; this without taking anything away from the antidepressant efficacy of the basic treatment, on the contrary, enhancing it with an increase in initiative, motivation and sense of pleasure that only dopamine can give. Among the dopaminergics in use and with few and mild side effects there is amantadine (Mantadan), initially used as an antiviral drug and then as an antiparkinsonian drug (Parkinson's disease is characterized by a decrease in dopaminergic tone in certain regions of the brain). More recently, amantadine has been appreciated as an adjuvant in antidepressant therapy when common antidepressants alone do not work. Certainly, the possible addition of Amantadine both as an enhancer of an insufficient antidepressant therapy and as a corrector of sexual disorders must be weighed by a doctor who knows this molecule well because there are some conditions or pathologies incompatible with its use. Read the full article on my website: https://www.angelomercuri.it/amantadi...

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